I realized when I posted my last essay that it was way too long for a blog. This is my attempt to reduce it down to a few paragraphs.
Reductionism in biology is the idea that all levels of enquiry, from cells to physiology to ecology, could in theory be explained by molecular biology, and ultimately by particle physics. Physicalism is the idea that there is only one kind of stuff in the universe, matter (or energy—pick your stuff). I find it strange that the majority of biologists and philosophers of science are both physicalists and anti-reductionists. It seems to me that not only does physicalism require a bedrock theory of reductionism, but that reductionism has proven to be the best strategy we have for understanding nature. I suspect that most anti-reductionists are fearful of determinism, and the debunking of free will that it entails, and this is the motivation behind the inconsistency.
One thing I didn’t explain in my first essay was the distinction between theoretical and ontological reductionism. To be fair, most scientists and philosophers are specifically opposed to theoretical reductionism, which is the belief that all higher level scientific theories will one day be explained in terms of particle physics. The classic example of theoretical reductionism is the reduction of Kepler’s laws of planetary motion to Newton’s laws of mechanics. There are fewer opponents to ontological reductionism, which is the belief that the physical world is ultimately made of one basic unit of physical stuff (this is also known as monism).
The view that anti-reductionists posit is called emergence. This is the idea that there are different levels of biological enquiry that require different kinds of explanation. Certain characteristics of the biological world emerge only when matter interacts in large quantities, creating complex systems with fascinating properties all of their own. The whole is more than the sum of its parts. A classic example of an emergent property in physics is color—an elementary particle doesn’t have a color, but a large collection of particles emit a certain spectrum of light and can then be said to have color.
[Stuart Kauffman (Reinventing the Sacred: A New View of Science, Reason, and Religion) is an example of someone who is a physicalist and at the same time rejects both theoretical and ontological reductionism. Not only does he think that certain properties of biology emerge at higher levels of complexity, he thinks those properties represent real fundamental units of reality (what he calls the “furniture of the universe”).]
Emergence and complex systems theory are fascinating to me, and I think they have a lot to contribute in the near future. Ultimately, though, the core of natural science is reductionistic, and I see no reason to doubt that complexity theories will one day be replaced with fundamental physical theories. This prospect is even more likely if it turns out to be true that the principle of natural selection is actually a law of chemistry, as Alexander Rosenberg has suggested (Darwinian Reductionism or How to Stop Worrying and Love Molecular Biology).
Thursday, September 4, 2008
Thursday, August 28, 2008
Reductionism
Richard Feynman once said that the two cultures of the sciences and the humanities, as famously described by C. P. Snow, are divided between those who understand mathematics well enough to appreciate its relationship to nature and those who have never had that experience. Although I don’t like the idea of there being two separate cultures in academia (however accurately it may describe the modern university), Feynman’s point is hard to deny. At a certain level, there can be no metaphorical understanding of the deep relationship between mathematics and nature, no way to translate the language of mathematics in order to convey its astounding predictive power in the physical universe. This must be experienced first hand, and the experience can change the way you see the world in profound ways.
I had a similar opinion about reductionism in biology. Reductionism is the idea that all levels of investigation in biology, from cells to organisms to populations and ecosystems, can ultimately be explained by molecular biology. This does not necessarily commit reductionism to what is commonly understood as genetic determinism, but it does imply molecular determinism. A reductionist would say that any meaningful explanation in biology will ultimately come from a description of how molecules at the biochemical level determine the phenomena in question. Non-reductionists—surprise, surprise—deny that all explanations in biology can be made in terms of molecules. They claim that some properties of biological systems “emerge” and that we cannot explain this emergence by a reduction to chemistry and physics.
Like Feynman, I suspected that the difference between reductionists and non-reductionists was a difference of experience. What separated the two, I thought, must be the level of familiarity with molecular and developmental biology. Those who had a cursory understanding of the relevant biology could be forgiven if they thought genetics and biochemistry couldn’t explain embryology, couldn’t explain adaptation, couldn’t even explain Mendelian genetics. Those who knew the facts would be convinced that reductionism was hard to deny.
Apparently, my suspicion was wrong. Or, rather, I was misled by my unintentionally selective reading of prominent biologists and philosophers. The issue of reductionism per se does not come up in biology textbooks, so my understanding of the larger conceptual framework of modern biology came from reading the few popular reductionists of our day: Watson and Crick, E. O. Wilson, Dawkins, and Dennett. I had been reading these authors before I took genetics, biochemistry, and developmental biology as an undergraduate, so it seemed natural to me that reductionism was alive and well in the realms of theoretical biology and the philosophy of science.
According to Alex Rosenberg (Darwinian Reductionism:Or, How to Stop Worrying and Love Molecular Biology), there are very few biologists and philosophers who are openly reductionistic. He finds this strange, considering the fact that the vast majority of these same non-reductionists are physicalists. The term physicalism is in conceptual opposition to the term dualism, an idea which Descartes is famous for. Dualism was an attempt to split reality into two different kinds of fundamental stuff—the physical world and the world of the mind or spirit. This idea encouraged progress in the physical sciences because it allowed philosophers/scientists to treat the physical world as a purely mechanical system which was accurately described by mathematics. Dualism, however, has fallen out of favor in philosophy and especially in the natural sciences. The main problem with dualism turned out to be the need to connect the two kinds of stuff. It seemed obvious that a person’s mind acted on its body (I mentally choose to lift my arm) and the body acted on the mind (I stub my toe and I am acutely aware of the pain in my mind) but no mechanism was discovered that could explain how this worked. Physicalism solves this problem by claiming that there is only one kind of stuff, the physical, and that the mind will eventually be explained by matter and its motion in space—a claim that has plenty of problems of its own.
What Rosenberg finds strange is that the majority of biologists and philosophers maintain the physicalist position and at the same time deny reductionism in biology. Again, physicalism is a mechanistic theory, or, I should say, it is a theory that there is one kind of stuff whose actions and reactions can be consistently described. This was done very successfully with Newtonian mechanics until the early 20th century. Today, physics is even more precise in its description of matter in motion, but it no longer describes a clockwork universe. Subatomic physics can only be described statistically, and this changed our conception of a purely physical universe which operates by consistent mechanical laws concerning matter in motion. However, quantum mechanics is still a physicalist approach to describing the one kind of stuff in our universe. Our understanding of quarks and electrons determines our understanding of atoms which determines our understanding of molecules and their chemical reactions. There is no gap in the line of explanation, which rests on our understanding of the brute statistical facts of subatomic particles: molecules and chemistry reduce to quarks and leptons. Non-reductionist biologists claim that there are facts in the biological world, from the level of the cell to the ecosystem, that are not explained by a line of reasoning that eventually leads to the quark and leptons. They claim that there are facts about the physical universe that are biological facts and essentially distinct from molecular/chemical facts. We are overdue for an example.
Meiosis is the process by which a cell splits to form gametes, which are units of sexual reproduction (sperm or egg).
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http://en.wikipedia.org/wiki/Image:MajorEventsInMeiosis.jpg
The objects inside the cell in the picture above are chromosomes containing DNA, and the process of meiosis is responsible for copying the entire genome of an organism so that a complete set of chromosomes is placed in each gamete. This process is fairly well understood at the molecular level, and it has been used for decades now to explain Mendelian inheritance. Mendel was the Russian monk in the 19th century who cultivated thousands of pea plants, and from his observations developed a theory of inheritance that postulated units of inheritance called alleles. These alleles were thought to be responsible for traits like color, size, and texture. His theory stated that each allele had two versions, one dominant and one recessive, and that each plant possessed two copies of each allele. Depending on the combination of alleles possessed by each pea, two peas are bread and produce a certain ratio of offspring that express the traits according to the presence of dominant alleles.
http://ib.berkeley.edu/courses/ib162/Week2a.htm
The picture above illustrates the inheritance of color in a pea. The two peas outside of the grid are the parents, and the arrows indicate the contribution of alleles from each pea. Each parent pea possesses a dominant allele (Y) and a recessive allele (y). In this case the dominant trait is the color yellow, hence the capital Y, and the presence of at least one dominant allele will give the daughter pea a yellow color. In the absence of a dominant allele, a green pea will be produced. Since each pea contributes one allele to a daughter, and there is a 50/50 chance that the allele contributed will be a Y or a y, then the grid above represents all of the possible combinations that could arise along with their frequencies. In other words, if there are 100 offspring produced from these two parents, there will likely be 25 YY offspring, 50 Yy, and 25 yy. This is a statistical result, so the numbers won’t be perfect, but the likely number of yellow offspring peas will be 75. This concept of parents having two alleles for each trait, which are randomly segregated and distributed to offspring, is known as the Law of Segregation.
The molecular mechanisms of meiosis seem to explain Mendelian genetics by identifying alleles as genetic units. In the picture of meiosis above, the chromosomes represent many, many alleles, which are matched by a “homologous” chromosome containing the other allele. For example, the human cell contains 46 chromosomes.
Each chromosome, containing a series of alleles, can be paired up with one other chromosome that contains a complementary series of alleles, as displayed in the picture above (22 chromosomes are matched by size and color—the 23rd set contains the sex chromosomes X and Y). For simplicity’s sake, imagine that chromosome 1 contains an allele for hair color, with (B) as the dominant allele yielding brown hair and (b) as the recessive allele. If hair color in humans was produced in children at the same frequencies of color found in Mendel’s peas, then it would make sense to predict that two parents with both a dominant allele and a recessive allele (Bb) x (Bb) will most likely have offspring of the frequency displayed in Mendel’s peas: 75% will have blond hair and 25% will have no B allele, yielding, let’s say, red hair. Most traits in humans don’t have such a simple outcome (including hair color), but that’s the basic idea behind inheritance in peas—alleles are genetic units located on chromosomes.
Now let’s consider two traits that are simultaneously passed on from parents to offspring. Imagine that the same two parents with both dominant and recessive alleles for blond hair on chromosome 1 (Bb) also possess both dominant and recessive alleles for big ears on chromosome 2 (Ee). The cross would be written as (Bb) (Ee) x (Bb) (Ee) and there would be four possible types of offspring: blonds with big ears, blonds with small ears, red-heads with big ears, and red-heads with small ears. What should we expect their frequencies to be?
When Mendel tested for two traits, color and roundness, he found that, if he bred peas that he suspected contained both dominant and recessive alleles for both traits [roundness, R, is a dominant trait—so by crossing (Yy) (Rr) x (Yy) (Rr) he had to have a reason to believe they contained those alleles, since the outward appearance of the peas would all be yellow and round, the same appearance of a pea with alleles (YY) (RR), etc.] he obtained a result that was consistent with the assumption that the alleles were not connected to each other. In other words, when considering all of the possibilities of offspring, it was accurate to assume that the alleles for color were distributed independently of the alleles for roundness.
http://ib.berkeley.edu/courses/ib162/Week2a.htm
The four types of offspring were yellow-round, green-round, yellow-wrinkled, and green wrinkled, at a ratio of 9 : 3 : 3 : 1, but each trait could be considered independently as before. Seventy-five percent were yellow, 25% were green, 75 % were round, and 25% were wrinkled. This is known as the Law of Independent Assortment.
Going back to our human example, it is clear why we would expect the same frequency as Mendel’s peas. We should get blond-big-ears, redhead-big-ears, blond-small-ears, and red-head-small-ears at 9 : 3 : 3 : 1; and 75% blond, 75% big-eared, 25% red-headed, and 25% small-eared. Why? Because hair color alleles and ear size alleles are on separate chromosomes.
When meiosis occurs, each homologous chromosome is randomly split among the gametes that are produced, making the likelihood of getting blond or red hair and getting big or small ears completely separate. If they were on the same chromosome, then we would not observe the same frequency as before. The likelihood of getting blond hair would be statistically connected to the likelihood of getting big ears. This molecular explanation seems to account for Mendel’s non-molecular observations more than a century ago: all independently assorting traits are on separate chromosomes [or they are far enough apart on the same chromosome for cross-over to cancel out the affect on the frequency].
This is all necessary to understand because the arguments against reductionism have been lodged at the very first step in biology, the step from biochemistry to cytology, which is the study of the cell. Technically, the process of meiosis is a cytological process, because it looks at the patterns of molecular behavior that comprise a certain function of the cell. In this case, the function is replication for sexual reproduction. Philip Kitcher (“1953 and All That: A Tale of Two Sciences” and “The Hegemony of Molecular Biology”) has argued that classical (Mendelian) genetics, as a cytological process, cannot be reduced to molecular biology. His beef is not with what I have been describing as the molecular explanation of chromosomes as the location of alleles. He is denying the possibility of explaining the entire process in terms of the chemistry of molecules. ‘Simply’ describing the atomic makeup of molecules and understanding the chemical details of their reactions will not, according to Kitcher, provide us with the kind of explanation that is required to understand classical genetics.
“We begin by asking why genes on nonhomologous chromosomes assort independently. The simple cytological story…answers the question. That story generates further questions. For example, we might inquire why nonhomologous chromosomes are distributed independently at meiosis. To answer this question we would describe the formation of the spindle and the migration of chromosomes to the poles of the spindle just before meiotic division. Once again, the narrative would generate yet further questions. Why do the chromosomes ‘condense’ at prophase? How is the spindle formed? Perhaps in answering these questions we would begin to introduce the chemical details of the process. Yet simply plugging a molecular account into the narratives offered at the previous stages would decrease the explanatory power of those narratives. What is relevant to answering our original question is the fact that nonhomologous chromosomes assort independently. What is relevant to the issue of why nonhomologous chromosomes assort independently is the fact that the chromosomes are not selectively oriented toward the poles of the spindle. In neither case are the molecular details relevant. Indeed, adding those details would only disguise the relevant factor.”
Kitcher realizes that there is an obvious reductionist response to this. The problem may simply be that we do not know enough of the molecular details at the moment, but, if and when we do, it will eventually be possible to reduce meiosis to the biochemistry of cellular molecules. Kitcher thinks this response misses the crucial point:
“Recall the original cytological explanation. It accounted for the transmission of genes by identifying meiosis as a process of a particular kind: a process in which paired entities (in this case, homologous chromosomes) are separated by force so that one member of each pair is assigned to a descendant entity (in this case, a gamete). Let us call processes of this kind PS-processes…PS-processes are heterogeneous from the molecular point of view. There are no constraints on the molecular structures of the entities that are paired or on the ways in which the fundamental forces combine to pair them and to separate them. The bonds can be forged and broken in innumerable ways: all that matters is that there be bonds that initially pair the entities in question and that are subsequently (somehow) broken. In some cases, bonds may be formed directly between constituent molecules of the entities in question; in others, hordes of accessory molecules may be involved. In some cases, the separation may occur because of the action of electromagnetic forces or even of nuclear forces; but it is easy to think of examples in which the separation is effected by the action of gravity. I claim, therefore, that PS-processes are realized in a motley of molecular ways.”
This idea, that a certain kind of biological process can be accomplished using a variety of constituents and a variety pathways, is called multiple realizability. In other words, in the biological world, it’s possible to imagine that the process of meiosis could be successfully accomplished using different molecules and different chemical or physical processes. Kitcher’s point is that, since there is not a universal molecular description of the process of meiosis in all organisms, then it is impossible to think that the general process, meiosis, can be reduced to specific molecular processes. This is sometimes referred to as the many-one problem: many molecular processes can accomplish a specific higher cellular process.
Not only does Kitcher argue that higher levels of investigation, such as cytology and physiology, have “autonomous levels of biological explanation” and cannot be reduced to molecular biology, but he also rejects the idea that any exchange between the levels of investigation must flow from the bottom up. Kitcher claims that explanation can proceed from the top down.
“For example, to understand the phenotype associated with a mutant limb-bud allele, one may begin by tracing the tissue geometry to an underlying molecular structure. The molecular constitution of the mutant allele gives rise to a nonfunctional protein, causing some abnormality in the internal structures of cells. The abnormality is reflected in peculiarities of cell shape, which, in turn, affects the spatial relations among the cells of the embryo. So far we have the unidirectional flow of explanation which the reductionist envisages. However, the subsequent course of explanation is different. Because of the abnormal tissue geometry, cells that are normally in contact fail to touch; because they do not touch, certain important molecules, which activate some batteries of genes, do not reach crucial cells; because the genes in question are not ‘switched on’ a needed morphogen is not produced; the result is an abnormal morphology in the limb.
“Reductionists may point out, quite correctly, that there is some very complex molecular description of the entire situation. The tissue geometry is, after all, a configuration of molecules. But this point is no more relevant than the comparable claim about the process of meiotic division in which alleles are distributed to gametes. Certain genes are not expressed because of the geometrical structure of the cells in the tissue: the pertinent cells are too far apart. However this is realized at the molecular level, our explanation must bring out the salient fact that it is the presence of a gap between cells that are normally adjacent that explains the non-expression of the genes. As in the example of allele transmission at meiosis, we lose sight of the important connections by attempting to treat the situation from a molecular point of view. As before, the point can be sharpened by considering situations in which radically different molecular configurations realize the crucial feature of the tissue geometry: situations in which heterogeneous molecular structures realize the breakdown of communication between the cells.”
Kitcher’s arguments make sense, and they have apparently been influential among philosophers of science. However, I’m not convinced and, since I’m in danger of making this essay way too long, I’ll give the short version why. The fact is, the capacity for computation is the only limiting factor in our understanding of molecular biology, and we are not close to reaching our limit yet. It is entirely possible that we will be able to obtain an accurate and precise description of molecules in motion within the cell so that the functions now understood at the cellular level (cytology) will be reduced to biochemistry. Kitcher’s response to this doesn’t account for the possibility of an extremely advanced understanding of biochemistry that will in fact provide an explanation of meiosis. This seems like an anti-climactic conclusion after such a long introduction to this issue (I’m basically saying, “Nuh-uh”), but I’m frankly dumb-founded to find out that so many biologists and philosophers espouse the antireductionist argument. If the history of western science teaches us anything, it is that those who wager against the progress of reductionism in scientific explanation usually end up losing the bet. There are famous exceptions to that right now (for example, the mind), but I can’t see a good reason to doubt that molecular biology will not continue its “hegemony” in the life sciences.
Two final points. The first is that Alex Rosenberg has proposed a very interesting theory that may strengthen the reductionist position. There are many issues in this topic of reductionism that I haven’t even mentioned (for a comprehensive summary, see the online Stanford Encyclopedia of Philosophy entry on Reductionism in Biology), one of them being the role of natural law in scientific explanation. There don’t appear to be laws in biology like there are in physics, and this poses problems for explanation in biology and, in turn, reductionism. The closest thing to a law in biology is the principle of natural selection (PNS), and this theory hasn’t been successfully reduced to a physical law. Rosenberg suggests that the PNS is actually a law of chemistry and can be observed at the molecular level in terms of the dynamic process of reaching a chemical equilibrium. Any chemical system (all molecules within a certain volume) with a definable starting point will posses a certain chemical milieu, with each molecule having a certain energetic relationship to its neighbors based on its chemical bonds. As time moves forward, the molecules that are energetically disposed to persisting in this milieu will remain in their original molecular composition longer, and it is possible that some molecules may lead to the kind of self-replication that must have occurred here on earth at the beginning of life. Biochemists who investigate the chemical origins of life have applied the PNS to chemistry for decades now, but Rosenberg claims that the PNS properly understood is a basic law of physical science. If this turns out to be true, I see no reason to doubt that biological explanation will one day be reduced to biochemical explanation.
The second point is that I suspect the strong resistance to reductionism by biologists and philosophers is a result in large part to their fear of determinism. This is the only explanation I can come up with to understand how the majority of scientists and philosophers are both physicalists and non-reductionists at the same time. Rosenberg spends an entire chapter explaining how reductionism actually disproves genetic determinism, by which he means the idea that a single gene uniquely determines a single trait in an organism. This is true, genetic determinism popularly understood does not hold water, but reductionism certainly entails molecular determinism. If all of biology can be reduced to the motion of molecules in space, then where does free will fit into the picture? Because I find reductionism so convincing, I also find it hard to deny determinism, and this leaves me in a moral dilemma. If there is no free will, how can one say that a person aught to do one thing as opposed to another? That will have to be a topic for another essay.
I had a similar opinion about reductionism in biology. Reductionism is the idea that all levels of investigation in biology, from cells to organisms to populations and ecosystems, can ultimately be explained by molecular biology. This does not necessarily commit reductionism to what is commonly understood as genetic determinism, but it does imply molecular determinism. A reductionist would say that any meaningful explanation in biology will ultimately come from a description of how molecules at the biochemical level determine the phenomena in question. Non-reductionists—surprise, surprise—deny that all explanations in biology can be made in terms of molecules. They claim that some properties of biological systems “emerge” and that we cannot explain this emergence by a reduction to chemistry and physics.
Like Feynman, I suspected that the difference between reductionists and non-reductionists was a difference of experience. What separated the two, I thought, must be the level of familiarity with molecular and developmental biology. Those who had a cursory understanding of the relevant biology could be forgiven if they thought genetics and biochemistry couldn’t explain embryology, couldn’t explain adaptation, couldn’t even explain Mendelian genetics. Those who knew the facts would be convinced that reductionism was hard to deny.
Apparently, my suspicion was wrong. Or, rather, I was misled by my unintentionally selective reading of prominent biologists and philosophers. The issue of reductionism per se does not come up in biology textbooks, so my understanding of the larger conceptual framework of modern biology came from reading the few popular reductionists of our day: Watson and Crick, E. O. Wilson, Dawkins, and Dennett. I had been reading these authors before I took genetics, biochemistry, and developmental biology as an undergraduate, so it seemed natural to me that reductionism was alive and well in the realms of theoretical biology and the philosophy of science.
According to Alex Rosenberg (Darwinian Reductionism:Or, How to Stop Worrying and Love Molecular Biology), there are very few biologists and philosophers who are openly reductionistic. He finds this strange, considering the fact that the vast majority of these same non-reductionists are physicalists. The term physicalism is in conceptual opposition to the term dualism, an idea which Descartes is famous for. Dualism was an attempt to split reality into two different kinds of fundamental stuff—the physical world and the world of the mind or spirit. This idea encouraged progress in the physical sciences because it allowed philosophers/scientists to treat the physical world as a purely mechanical system which was accurately described by mathematics. Dualism, however, has fallen out of favor in philosophy and especially in the natural sciences. The main problem with dualism turned out to be the need to connect the two kinds of stuff. It seemed obvious that a person’s mind acted on its body (I mentally choose to lift my arm) and the body acted on the mind (I stub my toe and I am acutely aware of the pain in my mind) but no mechanism was discovered that could explain how this worked. Physicalism solves this problem by claiming that there is only one kind of stuff, the physical, and that the mind will eventually be explained by matter and its motion in space—a claim that has plenty of problems of its own.
What Rosenberg finds strange is that the majority of biologists and philosophers maintain the physicalist position and at the same time deny reductionism in biology. Again, physicalism is a mechanistic theory, or, I should say, it is a theory that there is one kind of stuff whose actions and reactions can be consistently described. This was done very successfully with Newtonian mechanics until the early 20th century. Today, physics is even more precise in its description of matter in motion, but it no longer describes a clockwork universe. Subatomic physics can only be described statistically, and this changed our conception of a purely physical universe which operates by consistent mechanical laws concerning matter in motion. However, quantum mechanics is still a physicalist approach to describing the one kind of stuff in our universe. Our understanding of quarks and electrons determines our understanding of atoms which determines our understanding of molecules and their chemical reactions. There is no gap in the line of explanation, which rests on our understanding of the brute statistical facts of subatomic particles: molecules and chemistry reduce to quarks and leptons. Non-reductionist biologists claim that there are facts in the biological world, from the level of the cell to the ecosystem, that are not explained by a line of reasoning that eventually leads to the quark and leptons. They claim that there are facts about the physical universe that are biological facts and essentially distinct from molecular/chemical facts. We are overdue for an example.
Meiosis is the process by which a cell splits to form gametes, which are units of sexual reproduction (sperm or egg).
http://en.wikipedia.org/wiki/Image:MajorEventsInMeiosis.jpg
The objects inside the cell in the picture above are chromosomes containing DNA, and the process of meiosis is responsible for copying the entire genome of an organism so that a complete set of chromosomes is placed in each gamete. This process is fairly well understood at the molecular level, and it has been used for decades now to explain Mendelian inheritance. Mendel was the Russian monk in the 19th century who cultivated thousands of pea plants, and from his observations developed a theory of inheritance that postulated units of inheritance called alleles. These alleles were thought to be responsible for traits like color, size, and texture. His theory stated that each allele had two versions, one dominant and one recessive, and that each plant possessed two copies of each allele. Depending on the combination of alleles possessed by each pea, two peas are bread and produce a certain ratio of offspring that express the traits according to the presence of dominant alleles.
http://ib.berkeley.edu/courses/ib162/Week2a.htm
The picture above illustrates the inheritance of color in a pea. The two peas outside of the grid are the parents, and the arrows indicate the contribution of alleles from each pea. Each parent pea possesses a dominant allele (Y) and a recessive allele (y). In this case the dominant trait is the color yellow, hence the capital Y, and the presence of at least one dominant allele will give the daughter pea a yellow color. In the absence of a dominant allele, a green pea will be produced. Since each pea contributes one allele to a daughter, and there is a 50/50 chance that the allele contributed will be a Y or a y, then the grid above represents all of the possible combinations that could arise along with their frequencies. In other words, if there are 100 offspring produced from these two parents, there will likely be 25 YY offspring, 50 Yy, and 25 yy. This is a statistical result, so the numbers won’t be perfect, but the likely number of yellow offspring peas will be 75. This concept of parents having two alleles for each trait, which are randomly segregated and distributed to offspring, is known as the Law of Segregation.
The molecular mechanisms of meiosis seem to explain Mendelian genetics by identifying alleles as genetic units. In the picture of meiosis above, the chromosomes represent many, many alleles, which are matched by a “homologous” chromosome containing the other allele. For example, the human cell contains 46 chromosomes.
Each chromosome, containing a series of alleles, can be paired up with one other chromosome that contains a complementary series of alleles, as displayed in the picture above (22 chromosomes are matched by size and color—the 23rd set contains the sex chromosomes X and Y). For simplicity’s sake, imagine that chromosome 1 contains an allele for hair color, with (B) as the dominant allele yielding brown hair and (b) as the recessive allele. If hair color in humans was produced in children at the same frequencies of color found in Mendel’s peas, then it would make sense to predict that two parents with both a dominant allele and a recessive allele (Bb) x (Bb) will most likely have offspring of the frequency displayed in Mendel’s peas: 75% will have blond hair and 25% will have no B allele, yielding, let’s say, red hair. Most traits in humans don’t have such a simple outcome (including hair color), but that’s the basic idea behind inheritance in peas—alleles are genetic units located on chromosomes.Now let’s consider two traits that are simultaneously passed on from parents to offspring. Imagine that the same two parents with both dominant and recessive alleles for blond hair on chromosome 1 (Bb) also possess both dominant and recessive alleles for big ears on chromosome 2 (Ee). The cross would be written as (Bb) (Ee) x (Bb) (Ee) and there would be four possible types of offspring: blonds with big ears, blonds with small ears, red-heads with big ears, and red-heads with small ears. What should we expect their frequencies to be?
When Mendel tested for two traits, color and roundness, he found that, if he bred peas that he suspected contained both dominant and recessive alleles for both traits [roundness, R, is a dominant trait—so by crossing (Yy) (Rr) x (Yy) (Rr) he had to have a reason to believe they contained those alleles, since the outward appearance of the peas would all be yellow and round, the same appearance of a pea with alleles (YY) (RR), etc.] he obtained a result that was consistent with the assumption that the alleles were not connected to each other. In other words, when considering all of the possibilities of offspring, it was accurate to assume that the alleles for color were distributed independently of the alleles for roundness.
http://ib.berkeley.edu/courses/ib162/Week2a.htm
The four types of offspring were yellow-round, green-round, yellow-wrinkled, and green wrinkled, at a ratio of 9 : 3 : 3 : 1, but each trait could be considered independently as before. Seventy-five percent were yellow, 25% were green, 75 % were round, and 25% were wrinkled. This is known as the Law of Independent Assortment.
Going back to our human example, it is clear why we would expect the same frequency as Mendel’s peas. We should get blond-big-ears, redhead-big-ears, blond-small-ears, and red-head-small-ears at 9 : 3 : 3 : 1; and 75% blond, 75% big-eared, 25% red-headed, and 25% small-eared. Why? Because hair color alleles and ear size alleles are on separate chromosomes.
When meiosis occurs, each homologous chromosome is randomly split among the gametes that are produced, making the likelihood of getting blond or red hair and getting big or small ears completely separate. If they were on the same chromosome, then we would not observe the same frequency as before. The likelihood of getting blond hair would be statistically connected to the likelihood of getting big ears. This molecular explanation seems to account for Mendel’s non-molecular observations more than a century ago: all independently assorting traits are on separate chromosomes [or they are far enough apart on the same chromosome for cross-over to cancel out the affect on the frequency].
This is all necessary to understand because the arguments against reductionism have been lodged at the very first step in biology, the step from biochemistry to cytology, which is the study of the cell. Technically, the process of meiosis is a cytological process, because it looks at the patterns of molecular behavior that comprise a certain function of the cell. In this case, the function is replication for sexual reproduction. Philip Kitcher (“1953 and All That: A Tale of Two Sciences” and “The Hegemony of Molecular Biology”) has argued that classical (Mendelian) genetics, as a cytological process, cannot be reduced to molecular biology. His beef is not with what I have been describing as the molecular explanation of chromosomes as the location of alleles. He is denying the possibility of explaining the entire process in terms of the chemistry of molecules. ‘Simply’ describing the atomic makeup of molecules and understanding the chemical details of their reactions will not, according to Kitcher, provide us with the kind of explanation that is required to understand classical genetics.
“We begin by asking why genes on nonhomologous chromosomes assort independently. The simple cytological story…answers the question. That story generates further questions. For example, we might inquire why nonhomologous chromosomes are distributed independently at meiosis. To answer this question we would describe the formation of the spindle and the migration of chromosomes to the poles of the spindle just before meiotic division. Once again, the narrative would generate yet further questions. Why do the chromosomes ‘condense’ at prophase? How is the spindle formed? Perhaps in answering these questions we would begin to introduce the chemical details of the process. Yet simply plugging a molecular account into the narratives offered at the previous stages would decrease the explanatory power of those narratives. What is relevant to answering our original question is the fact that nonhomologous chromosomes assort independently. What is relevant to the issue of why nonhomologous chromosomes assort independently is the fact that the chromosomes are not selectively oriented toward the poles of the spindle. In neither case are the molecular details relevant. Indeed, adding those details would only disguise the relevant factor.”
Kitcher realizes that there is an obvious reductionist response to this. The problem may simply be that we do not know enough of the molecular details at the moment, but, if and when we do, it will eventually be possible to reduce meiosis to the biochemistry of cellular molecules. Kitcher thinks this response misses the crucial point:
“Recall the original cytological explanation. It accounted for the transmission of genes by identifying meiosis as a process of a particular kind: a process in which paired entities (in this case, homologous chromosomes) are separated by force so that one member of each pair is assigned to a descendant entity (in this case, a gamete). Let us call processes of this kind PS-processes…PS-processes are heterogeneous from the molecular point of view. There are no constraints on the molecular structures of the entities that are paired or on the ways in which the fundamental forces combine to pair them and to separate them. The bonds can be forged and broken in innumerable ways: all that matters is that there be bonds that initially pair the entities in question and that are subsequently (somehow) broken. In some cases, bonds may be formed directly between constituent molecules of the entities in question; in others, hordes of accessory molecules may be involved. In some cases, the separation may occur because of the action of electromagnetic forces or even of nuclear forces; but it is easy to think of examples in which the separation is effected by the action of gravity. I claim, therefore, that PS-processes are realized in a motley of molecular ways.”
This idea, that a certain kind of biological process can be accomplished using a variety of constituents and a variety pathways, is called multiple realizability. In other words, in the biological world, it’s possible to imagine that the process of meiosis could be successfully accomplished using different molecules and different chemical or physical processes. Kitcher’s point is that, since there is not a universal molecular description of the process of meiosis in all organisms, then it is impossible to think that the general process, meiosis, can be reduced to specific molecular processes. This is sometimes referred to as the many-one problem: many molecular processes can accomplish a specific higher cellular process.
Not only does Kitcher argue that higher levels of investigation, such as cytology and physiology, have “autonomous levels of biological explanation” and cannot be reduced to molecular biology, but he also rejects the idea that any exchange between the levels of investigation must flow from the bottom up. Kitcher claims that explanation can proceed from the top down.
“For example, to understand the phenotype associated with a mutant limb-bud allele, one may begin by tracing the tissue geometry to an underlying molecular structure. The molecular constitution of the mutant allele gives rise to a nonfunctional protein, causing some abnormality in the internal structures of cells. The abnormality is reflected in peculiarities of cell shape, which, in turn, affects the spatial relations among the cells of the embryo. So far we have the unidirectional flow of explanation which the reductionist envisages. However, the subsequent course of explanation is different. Because of the abnormal tissue geometry, cells that are normally in contact fail to touch; because they do not touch, certain important molecules, which activate some batteries of genes, do not reach crucial cells; because the genes in question are not ‘switched on’ a needed morphogen is not produced; the result is an abnormal morphology in the limb.
“Reductionists may point out, quite correctly, that there is some very complex molecular description of the entire situation. The tissue geometry is, after all, a configuration of molecules. But this point is no more relevant than the comparable claim about the process of meiotic division in which alleles are distributed to gametes. Certain genes are not expressed because of the geometrical structure of the cells in the tissue: the pertinent cells are too far apart. However this is realized at the molecular level, our explanation must bring out the salient fact that it is the presence of a gap between cells that are normally adjacent that explains the non-expression of the genes. As in the example of allele transmission at meiosis, we lose sight of the important connections by attempting to treat the situation from a molecular point of view. As before, the point can be sharpened by considering situations in which radically different molecular configurations realize the crucial feature of the tissue geometry: situations in which heterogeneous molecular structures realize the breakdown of communication between the cells.”
Kitcher’s arguments make sense, and they have apparently been influential among philosophers of science. However, I’m not convinced and, since I’m in danger of making this essay way too long, I’ll give the short version why. The fact is, the capacity for computation is the only limiting factor in our understanding of molecular biology, and we are not close to reaching our limit yet. It is entirely possible that we will be able to obtain an accurate and precise description of molecules in motion within the cell so that the functions now understood at the cellular level (cytology) will be reduced to biochemistry. Kitcher’s response to this doesn’t account for the possibility of an extremely advanced understanding of biochemistry that will in fact provide an explanation of meiosis. This seems like an anti-climactic conclusion after such a long introduction to this issue (I’m basically saying, “Nuh-uh”), but I’m frankly dumb-founded to find out that so many biologists and philosophers espouse the antireductionist argument. If the history of western science teaches us anything, it is that those who wager against the progress of reductionism in scientific explanation usually end up losing the bet. There are famous exceptions to that right now (for example, the mind), but I can’t see a good reason to doubt that molecular biology will not continue its “hegemony” in the life sciences.
Two final points. The first is that Alex Rosenberg has proposed a very interesting theory that may strengthen the reductionist position. There are many issues in this topic of reductionism that I haven’t even mentioned (for a comprehensive summary, see the online Stanford Encyclopedia of Philosophy entry on Reductionism in Biology), one of them being the role of natural law in scientific explanation. There don’t appear to be laws in biology like there are in physics, and this poses problems for explanation in biology and, in turn, reductionism. The closest thing to a law in biology is the principle of natural selection (PNS), and this theory hasn’t been successfully reduced to a physical law. Rosenberg suggests that the PNS is actually a law of chemistry and can be observed at the molecular level in terms of the dynamic process of reaching a chemical equilibrium. Any chemical system (all molecules within a certain volume) with a definable starting point will posses a certain chemical milieu, with each molecule having a certain energetic relationship to its neighbors based on its chemical bonds. As time moves forward, the molecules that are energetically disposed to persisting in this milieu will remain in their original molecular composition longer, and it is possible that some molecules may lead to the kind of self-replication that must have occurred here on earth at the beginning of life. Biochemists who investigate the chemical origins of life have applied the PNS to chemistry for decades now, but Rosenberg claims that the PNS properly understood is a basic law of physical science. If this turns out to be true, I see no reason to doubt that biological explanation will one day be reduced to biochemical explanation.
The second point is that I suspect the strong resistance to reductionism by biologists and philosophers is a result in large part to their fear of determinism. This is the only explanation I can come up with to understand how the majority of scientists and philosophers are both physicalists and non-reductionists at the same time. Rosenberg spends an entire chapter explaining how reductionism actually disproves genetic determinism, by which he means the idea that a single gene uniquely determines a single trait in an organism. This is true, genetic determinism popularly understood does not hold water, but reductionism certainly entails molecular determinism. If all of biology can be reduced to the motion of molecules in space, then where does free will fit into the picture? Because I find reductionism so convincing, I also find it hard to deny determinism, and this leaves me in a moral dilemma. If there is no free will, how can one say that a person aught to do one thing as opposed to another? That will have to be a topic for another essay.
Tuesday, May 20, 2008
Evangelical Fundamentalism
My friend John at The Daily Detour recently asked the question, “Why do so many reject the Christian faith?” I thought I would post my comment here:
[That is a good question], John. You and I have talked at length about why I rejected the Christian faith, but as far as the “so many” out there that have rejected Christianity, it’s hard to give a complete answer. There are a variety of different brands of Christianity, and you may find that people have rejected Anglicanism in England for reasons totally inapplicable to evangelicalism in the U.S. My thinking along these lines has been influenced by George Marsden’s “Understanding Fundamentalism and Evangelicalism”.
As you know, in my case, going to the university and getting a good grounding in natural sciences had a lot to do with me eventually rejecting the Christian faith. But according to evangelical fundamentalists in the United States, I was rejecting the Christian faith the moment I even considered evolution to be true. Marsden defines a fundamentalist as “an evangelical who is militant in opposition to liberal theology in the churches or to changes in cultural values or mores, such as those associated with ‘secular humanism.’” One of the things fundamentalists are “militantly” opposed to is evolution. So, if the only brand of Christianity I was familiar with was evangelical fundamentalism, then I was forced to make a choice in my young intellectual life: reject the foundational theory of modern biology or reject Christianity.
Of course, by the time I was considering this dilemma, I had become aware of more liberal Christianities that didn’t reject the validity of evolution. But I really didn’t know any of those people in the flesh. So the fundamentalist brand represented real Christianity to me, and I could no longer believe it.
What’s interesting about the history of this form of evangelicalism is that it didn’t develop out of a long history of opposition to science. In fact, just the opposite. It was a result of the natural theology of the 18th and 19th century, of the William Paley variety. Before Darwin, many Christians were confident that there was a complete harmony between Christian theology and natural science. Science merely confirmed empirically what the Bible already told us. According to Marsden, this was part and parcel of the Enlightenment, not a counter-Enlightenment. The Bible was perceived as a scientific book, which contained positive statements about the world that could be understood and believed in with certainty. Even the revolution in the study of geology in the first half of the 19th century didn’t produce much opposition from Bible believers. Most evangelicals who were aware of this development were willing to consider the “days” of Genesis 1 to be “ages,” since the earth appeared to be more than 6,000 years old.
Then Darwin happened. But, apparently, there wasn’t as vehement an opposition to it among evangelicals as someone like Dawkins would want you to believe. At the beginning, the “war between science and Christianity” frame to the debate was promoted and maintained by the Darwinists, such as Huxley. There was certainly a debate, but many respected evangelicals accepted a theistic version of evolution and were not rejected by the evangelical community because of it. In fact Darwin’s first big proponent in the United States was Harvard’s Asa Gray, who was a respected evangelical.
Fundamentalism didn’t show up in the U.S. until about the 1920s. What happened in the meantime (between the 1880s, when natural selection became widely accepted in academic community, and the early 20th century) was the birth of the modern research university: specialization, professionalization, and a concerted effort to keep theology out of the laboratory. This is about the time that evangelicals started seeing a much bigger trend of sending their children to the university where they subsequently lost their faith. The assumption that the natural sciences would only serve to provide evidence for the truth of the Bible seemed to be backfiring. But instead of maintaining that front (the warfare terminology is creeping in here) and redoubling their efforts to show that there was no real conflict between science and Christianity, some evangelicals rejected the foundational theory of modern life sciences altogether. They made it a condition of their Christianity. And they guaranteed the alienation of an even larger proportion of young people who would go off to the “secular university” and have to make a choice between the version of Christianity that they knew and their intellectual integrity in the modern world.
As I’ve said [elsewhere], there have always been different Christianities, and some evangelical communities haven’t allowed themselves to be drawn into the battle between science and Christianity. Francis Collins’ book [The Language of God] is just the latest example of an evangelical who is trying to tone down the warfare rhetoric. I don’t know how well he’s been received among fundamentalist leaning evangelicals. Perhaps re-naming theistic evolution as bio-logos will do the trick. We’ll see.
[That is a good question], John. You and I have talked at length about why I rejected the Christian faith, but as far as the “so many” out there that have rejected Christianity, it’s hard to give a complete answer. There are a variety of different brands of Christianity, and you may find that people have rejected Anglicanism in England for reasons totally inapplicable to evangelicalism in the U.S. My thinking along these lines has been influenced by George Marsden’s “Understanding Fundamentalism and Evangelicalism”.
As you know, in my case, going to the university and getting a good grounding in natural sciences had a lot to do with me eventually rejecting the Christian faith. But according to evangelical fundamentalists in the United States, I was rejecting the Christian faith the moment I even considered evolution to be true. Marsden defines a fundamentalist as “an evangelical who is militant in opposition to liberal theology in the churches or to changes in cultural values or mores, such as those associated with ‘secular humanism.’” One of the things fundamentalists are “militantly” opposed to is evolution. So, if the only brand of Christianity I was familiar with was evangelical fundamentalism, then I was forced to make a choice in my young intellectual life: reject the foundational theory of modern biology or reject Christianity.
Of course, by the time I was considering this dilemma, I had become aware of more liberal Christianities that didn’t reject the validity of evolution. But I really didn’t know any of those people in the flesh. So the fundamentalist brand represented real Christianity to me, and I could no longer believe it.
What’s interesting about the history of this form of evangelicalism is that it didn’t develop out of a long history of opposition to science. In fact, just the opposite. It was a result of the natural theology of the 18th and 19th century, of the William Paley variety. Before Darwin, many Christians were confident that there was a complete harmony between Christian theology and natural science. Science merely confirmed empirically what the Bible already told us. According to Marsden, this was part and parcel of the Enlightenment, not a counter-Enlightenment. The Bible was perceived as a scientific book, which contained positive statements about the world that could be understood and believed in with certainty. Even the revolution in the study of geology in the first half of the 19th century didn’t produce much opposition from Bible believers. Most evangelicals who were aware of this development were willing to consider the “days” of Genesis 1 to be “ages,” since the earth appeared to be more than 6,000 years old.
Then Darwin happened. But, apparently, there wasn’t as vehement an opposition to it among evangelicals as someone like Dawkins would want you to believe. At the beginning, the “war between science and Christianity” frame to the debate was promoted and maintained by the Darwinists, such as Huxley. There was certainly a debate, but many respected evangelicals accepted a theistic version of evolution and were not rejected by the evangelical community because of it. In fact Darwin’s first big proponent in the United States was Harvard’s Asa Gray, who was a respected evangelical.
Fundamentalism didn’t show up in the U.S. until about the 1920s. What happened in the meantime (between the 1880s, when natural selection became widely accepted in academic community, and the early 20th century) was the birth of the modern research university: specialization, professionalization, and a concerted effort to keep theology out of the laboratory. This is about the time that evangelicals started seeing a much bigger trend of sending their children to the university where they subsequently lost their faith. The assumption that the natural sciences would only serve to provide evidence for the truth of the Bible seemed to be backfiring. But instead of maintaining that front (the warfare terminology is creeping in here) and redoubling their efforts to show that there was no real conflict between science and Christianity, some evangelicals rejected the foundational theory of modern life sciences altogether. They made it a condition of their Christianity. And they guaranteed the alienation of an even larger proportion of young people who would go off to the “secular university” and have to make a choice between the version of Christianity that they knew and their intellectual integrity in the modern world.
As I’ve said [elsewhere], there have always been different Christianities, and some evangelical communities haven’t allowed themselves to be drawn into the battle between science and Christianity. Francis Collins’ book [The Language of God] is just the latest example of an evangelical who is trying to tone down the warfare rhetoric. I don’t know how well he’s been received among fundamentalist leaning evangelicals. Perhaps re-naming theistic evolution as bio-logos will do the trick. We’ll see.
Friday, January 4, 2008
Me and the University: We (Non-)Scholars
I have finally graduated with two undergraduate degrees: one in biology and the other in English literature. It took me ten years to do it, six years of full time study, and I’m glad that it’s over. That’s not to say that I don’t like school any more. In fact, I kind of miss it already. But I’m apprehensive about returning as a graduate student. For some time now, I think I have moved beyond the undergraduate level of understanding the sciences and the humanities, but I don’t think I’d fit in very well as a graduate student. In many ways, my interests and writings are too broad and too unfocused. I’ve become a motivated scholar, I think, but apparently I’m not a very good one.
If a scholar is “one who has profound knowledge of a particular subject,” as the American Heritage Dictionary defines it, then I would rather not be one. And, of course, this is the purpose of a modern graduate education at the university: to obtain profound knowledge of a particular (i.e. specialized) subject. I know that I am generalizing, and that it is probably possible to get a broad education in an interdisciplinary graduate program, but those are few and far between. I also realize that specialization at the graduate level is to some degree necessary. The frontier of progress in of the disciplines has moved beyond the point where any layperson could comfortably peruse. My problem is that I am not comfortable with being a layperson. My ambition is to be literate in all of the major disciplines.
This ambition may be partially motivated by ego (all ambitions are), but it is also partially motivated by the realization that there is a unity to knowledge. Profound knowledge of just one, or maybe two, subjects cannot be very profound at all. Profundity requires not just detailed knowledge of the topic at hand but also an understanding of how it relates to the other disciplines and the larger world. A lifetime of studying the genes of fruit flies may make for a great academic career, but without a serious study of the impact this research has on the rest of biology, medicine, the philosophy of nature and ethics, I find it hard to believe that it would be profound. It is hard work, no doubt. It takes a special mind with special abilities. But this is work done in technical jargon with relatively narrow immediate goals and interests, and the geneticist who fails to go beyond it fails the minimum requirement for profundity. In this respect, there is little difference between the genetic specialist and the philosopher of symbolic logic, or the historian of amateur sports in the late 20th century, or the marxist professor of post-colonial Caribbean poetry.
The problem with wanting to be literate in all of the basic sciences and humanities is that it takes a lot of time and effort. But it is not impossible. Yet no one is really expected to master all (or even most) of them at the university any more, let alone outside of it. This is an unforeseen consequence of an undeniably good development in higher education: more people are going to colleges and universities. I’m not complaining about social progress in education, but merely following what I see as a line of cause and effect. In order to accommodate for more students with a greater range of intellectual abilities, universities have required less and less of their students. The motivation for this isn’t suspect, and I don’t think that this was a mistake in the long run. But the fact remains that a broad liberal education is a rare thing, and there is little encouragement for students to do anything other than pursue an incredibly specialized field or two.
Here is the dilemma: I'm not sure that I will be happy pursuing a masters or doctorate because of the narrow focus that will be expected of me, but I want to be around the kind of people that are at universities. I want to talk and interact with other people who are thinking about the same things that I am. Yes, it’s possible to study on my own, but I don’t want to be isolated from the conversation. I may not like the university culture, but it is the only intellectual culture in town.
—The scholar is that man who must take up into himself all the ability of the time, all the contributions of the past, all the hopes of the future. He must be an university of knowledges.
Emerson’s Phi Beta Kappa address at Harvard, 1837
—Late nineteenth-century university reformers did not reject the ideal of the unity of truth…On the contrary, they hoped to create new institutional forms that would embody their belief that truth incorporated all knowledge and was morally relevant, and also provide the basis for scholarly progress. These proved to be incompatible goals. For decades reformers unsuccessfully struggled to create universities that would serve the moral aims of the classical college while contributing to the advancement of knowledge. The educational and scholarly practices that emerged from their efforts encouraged specialization rather than intellectual synthesis.
Julie A. Reuben, The Making of the Modern University
—The thing being made in the university is humanity. Given the current influence of universities, this is merely inevitable. But what universities, at least publicly supported ones, are mandated to make or to help to make is human beings in the fullest sense of those words—not just trained workers or knowledgeable citizens but responsible heirs and members of human culture.
Wendell Berry, “The Loss of the University,” 1984
—In looking at [a teen-ager leaving home for the first time] we are forced to reflect on what [this person] should learn if he [or she] is to be called educated; we must speculate on what the human potential to be fulfilled is. In the specialties we can avoid such speculation, and the avoidance of them is one of specialization’s charms. But here it is a simple duty. What are we to teach this person? The answer may not be evident, but to attempt to answer the question is already to philosophize and to begin to educate.
Allan Bloom, The Closing of the American Mind, 1987
If a scholar is “one who has profound knowledge of a particular subject,” as the American Heritage Dictionary defines it, then I would rather not be one. And, of course, this is the purpose of a modern graduate education at the university: to obtain profound knowledge of a particular (i.e. specialized) subject. I know that I am generalizing, and that it is probably possible to get a broad education in an interdisciplinary graduate program, but those are few and far between. I also realize that specialization at the graduate level is to some degree necessary. The frontier of progress in of the disciplines has moved beyond the point where any layperson could comfortably peruse. My problem is that I am not comfortable with being a layperson. My ambition is to be literate in all of the major disciplines.
This ambition may be partially motivated by ego (all ambitions are), but it is also partially motivated by the realization that there is a unity to knowledge. Profound knowledge of just one, or maybe two, subjects cannot be very profound at all. Profundity requires not just detailed knowledge of the topic at hand but also an understanding of how it relates to the other disciplines and the larger world. A lifetime of studying the genes of fruit flies may make for a great academic career, but without a serious study of the impact this research has on the rest of biology, medicine, the philosophy of nature and ethics, I find it hard to believe that it would be profound. It is hard work, no doubt. It takes a special mind with special abilities. But this is work done in technical jargon with relatively narrow immediate goals and interests, and the geneticist who fails to go beyond it fails the minimum requirement for profundity. In this respect, there is little difference between the genetic specialist and the philosopher of symbolic logic, or the historian of amateur sports in the late 20th century, or the marxist professor of post-colonial Caribbean poetry.
The problem with wanting to be literate in all of the basic sciences and humanities is that it takes a lot of time and effort. But it is not impossible. Yet no one is really expected to master all (or even most) of them at the university any more, let alone outside of it. This is an unforeseen consequence of an undeniably good development in higher education: more people are going to colleges and universities. I’m not complaining about social progress in education, but merely following what I see as a line of cause and effect. In order to accommodate for more students with a greater range of intellectual abilities, universities have required less and less of their students. The motivation for this isn’t suspect, and I don’t think that this was a mistake in the long run. But the fact remains that a broad liberal education is a rare thing, and there is little encouragement for students to do anything other than pursue an incredibly specialized field or two.
Here is the dilemma: I'm not sure that I will be happy pursuing a masters or doctorate because of the narrow focus that will be expected of me, but I want to be around the kind of people that are at universities. I want to talk and interact with other people who are thinking about the same things that I am. Yes, it’s possible to study on my own, but I don’t want to be isolated from the conversation. I may not like the university culture, but it is the only intellectual culture in town.
—The scholar is that man who must take up into himself all the ability of the time, all the contributions of the past, all the hopes of the future. He must be an university of knowledges.
Emerson’s Phi Beta Kappa address at Harvard, 1837
—Late nineteenth-century university reformers did not reject the ideal of the unity of truth…On the contrary, they hoped to create new institutional forms that would embody their belief that truth incorporated all knowledge and was morally relevant, and also provide the basis for scholarly progress. These proved to be incompatible goals. For decades reformers unsuccessfully struggled to create universities that would serve the moral aims of the classical college while contributing to the advancement of knowledge. The educational and scholarly practices that emerged from their efforts encouraged specialization rather than intellectual synthesis.
Julie A. Reuben, The Making of the Modern University
—The thing being made in the university is humanity. Given the current influence of universities, this is merely inevitable. But what universities, at least publicly supported ones, are mandated to make or to help to make is human beings in the fullest sense of those words—not just trained workers or knowledgeable citizens but responsible heirs and members of human culture.
Wendell Berry, “The Loss of the University,” 1984
—In looking at [a teen-ager leaving home for the first time] we are forced to reflect on what [this person] should learn if he [or she] is to be called educated; we must speculate on what the human potential to be fulfilled is. In the specialties we can avoid such speculation, and the avoidance of them is one of specialization’s charms. But here it is a simple duty. What are we to teach this person? The answer may not be evident, but to attempt to answer the question is already to philosophize and to begin to educate.
Allan Bloom, The Closing of the American Mind, 1987
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